Double-negative-2 B cells are the major synovial plasma cell precursor in rheumatoid arthritis

Double-negative-2 B cells are the major synovial plasma cell precursor in rheumatoid arthritis

B cells are key pathogenic drivers of chronic inflammation in rheumatoid arthritis (RA). There is limited understanding of the relationship between synovial B cell subsets and pathogenic antibody secreting cells (ASCs). This knowledge is crucial for the development of more targeted B-cell depleting...

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Bibliographic Details
Main Authors: Elinor Wing, Catherine Sutherland, Katherine Miles, David Gray, Carl S. Goodyear, Thomas D. Otto, Stefan Breusch, Graeme Cowan, Mohini Gray
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
double-negative-2 (DN2) B cells
antibody secreting cells
synovium
single-cell sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1241474/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1241474/full

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