Increased frequency of β cells with abnormal NKX6.1 expression in type 2 diabetes but not in subjects with higher risk for type 2 diabetes

Increased frequency of β cells with abnormal NKX6.1 expression in type 2 diabetes but not in subjects with higher risk for type 2 diabetes

Abstract Background NKX6.1 is a transcription factor for insulin, as well as a marker for β cell maturity. Abnormal NKX6.1 expression in β cells, such as translocation from the nucleus to cytoplasm or lost expression, has been shown as a marker for β cell dedifferentiation. Methods We obtained pancr...

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Bibliographic Details
Main Authors: Tengli Liu, Peng Sun, Jiaqi Zou, Le Wang, Guanqiao Wang, Na Liu, Yaojuan Liu, Xuejie Ding, Boya Zhang, Rui Liang, Shusen Wang, Zhongyang Shen
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Endocrine Disorders
Subjects:
NKX6.1
Age
Obesity
HbA1c
β-Cell dedifferentiation
Online Access:https://doi.org/10.1186/s12902-021-00708-7

Internet

https://doi.org/10.1186/s12902-021-00708-7

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