Recruitment, Retainment, and Biomarkers of Response; A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment

Recruitment, Retainment, and Biomarkers of Response; A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment

Lithium has been used for decades to treat Bipolar Disorder. Some of its therapeutic benefits may be through inhibition of Glycogen Synthase Kinase (GSK)-3. Enhanced GSK3 activity associates with development of Alzheimer’s disease (AD), therefore lithium is a currently used therapeutic with potentia...

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Bibliographic Details
Main Authors: Ashleigh Duthie, Lidy van Aalten, Cara MacDonald, Alison McNeilly, Jennifer Gallagher, John Geddes, Simon Lovestone, Calum Sutherland
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
lithium
GSK3
clinical trial
biomarker
safety
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00163/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00163/full

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