Comparative Stability Study of Polysorbate 20 and Polysorbate 80 Related to Oxidative Degradation

Comparative Stability Study of Polysorbate 20 and Polysorbate 80 Related to Oxidative Degradation

The surfactants polysorbate 20 (PS20) and polysorbate 80 (PS80) are utilized to stabilize protein drugs. However, concerns have been raised regarding the degradation of PSs in biologics and the potential impact on product quality. Oxidation has been identified as a prevalent degradation mechanism un...

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Bibliographic Details
Main Authors: Benedykt Kozuch, Johanna Weber, Julia Buske, Karsten Mäder, Patrick Garidel, Tim Diederichs
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceutics
Subjects:
biotherapeutic formulations
surfactants
polysorbates
polysorbate stability
Tween<sup>®</sup>
autoxidation
Online Access:https://www.mdpi.com/1999-4923/15/9/2332

Internet

https://www.mdpi.com/1999-4923/15/9/2332

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