Targeting Translation and the Cell Cycle Inversely Affects CTC Metabolism but Not Metastasis

Targeting Translation and the Cell Cycle Inversely Affects CTC Metabolism but Not Metastasis

Melanoma brain metastasis (MBM) is significantly associated with poor prognosis and is diagnosed in 80% of patients at autopsy. Circulating tumor cells (CTCs) are “seeds” of metastasis and the smallest functional units of cancer. Our multilevel approach has previously identified a CTC RPL/RPS gene s...

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Bibliographic Details
Main Authors: Tetiana Y. Bowley, Seth D. Merkley, Irina V. Lagutina, Mireya C. Ortiz, Margaret Lee, Bernard Tawfik, Dario Marchetti
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cancers
Subjects:
circulating tumor cells (CTCs)
metastatic melanoma
omacetaxine
palbociclib
cell metabolism
translational inhibition
Online Access:https://www.mdpi.com/2072-6694/15/21/5263

Internet

https://www.mdpi.com/2072-6694/15/21/5263

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