Mechanistic Insights into the Role of OPN in Mediating Brain Damage via Triggering Lysosomal Damage in Microglia/Macrophage

Mechanistic Insights into the Role of OPN in Mediating Brain Damage via Triggering Lysosomal Damage in Microglia/Macrophage

We previously found that osteopontin (OPN) played a role in hypoxia–ischemia (HI) brain damage. However, its underlying mechanism is still unknown. Bioinformatics analysis revealed that the OPN protein was linked to the lysosomal cathepsin B (CTSB) and galectin-3 (GAL-3) proteins after HI exposure....

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Bibliographic Details
Main Authors: Chengcheng Gai, Yijing Zhao, Danqing Xin, Tingting Li, Yahong Cheng, Zige Jiang, Yan Song, Dexiang Liu, Zhen Wang
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
osteopontin
galectin-3
microglia/macrophages
lysosomal
cathepsin B
hypoxia–ischemia
Online Access:https://www.mdpi.com/2073-4409/12/6/854

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https://www.mdpi.com/2073-4409/12/6/854

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