Mechanistic Insights into the Role of OPN in Mediating Brain Damage via Triggering Lysosomal Damage in Microglia/Macrophage
We previously found that osteopontin (OPN) played a role in hypoxia–ischemia (HI) brain damage. However, its underlying mechanism is still unknown. Bioinformatics analysis revealed that the OPN protein was linked to the lysosomal cathepsin B (CTSB) and galectin-3 (GAL-3) proteins after HI exposure....
Main Authors: | Chengcheng Gai, Yijing Zhao, Danqing Xin, Tingting Li, Yahong Cheng, Zige Jiang, Yan Song, Dexiang Liu, Zhen Wang |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-03-01
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Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/12/6/854 |
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