Liquiritin ameliorates painful diabetic neuropathy in SD rats by inhibiting NLRP3-MMP-9-mediated reversal of aquaporin-4 polarity in the glymphatic system

Liquiritin ameliorates painful diabetic neuropathy in SD rats by inhibiting NLRP3-MMP-9-mediated reversal of aquaporin-4 polarity in the glymphatic system

BackgroundDespite advancements in diabetes treatment, the management of Painful Diabetic Neuropathy (PDN) remains challenging. Our previous research indicated a significant correlation between the expression and distribution of Aquaporin-4 (AQP4) in the spinal glymphatic system and PDN. However, the...

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Bibliographic Details
Main Authors: Shuai-Ying Jia, Wen-Qin Yin, Wen-Mei Xu, Jiang Li, Wei Yan, Jing-Yan Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Pharmacology
Subjects:
painful diabetic neuropathy
glymphatic system
aquaporin-4
liquiritin
matrix metalloproteinase-9
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1436146/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1436146/full

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