Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo[a]pyrene via ROS/NF-κB/NLRP3/Caspase-1 Signaling Pathway

Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo[a]pyrene via ROS/NF-κB/NLRP3/Caspase-1 Signaling Pathway

Isoorientin (Iso), a natural bioactive flavonoid, possesses significant anti-tumor and anti-oxidant activities. Benzo[a]pyrene (BaP) is a food processing injurant with carcinogenicity, teratogenicity, and genotoxicity. Our preliminary study demonstrates that Iso attenuated the pyroptotic hepatocyte...

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Bibliographic Details
Main Authors: Hao Li, Li Yuan, Xueyi Li, Ying Luo, Zhong Zhang, Jianke Li
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antioxidants
Subjects:
isoorientin
benzo[a]pyrene
pyroptosis
ROS
NF-κB
NLRP3
Online Access:https://www.mdpi.com/2076-3921/10/8/1275

Internet

https://www.mdpi.com/2076-3921/10/8/1275

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