Identification and Characterization of a Novel Epitope of ASFV-Encoded dUTPase by Monoclonal Antibodies

Identification and Characterization of a Novel Epitope of ASFV-Encoded dUTPase by Monoclonal Antibodies

Deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) of African swine fever virus (ASFV) is an essential enzyme required for efficient virus replication. Previous crystallography data have indicated that dUTPase (E165R) may serve as a therapeutic target for inhibiting ASFV replication; however...

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Bibliographic Details
Main Authors: Shuai Zhang, Rui Wang, Xiaojing Zhu, Jiaxin Jin, Wenlong Lu, Xuyang Zhao, Bo Wan, Yifei Liao, Qin Zhao, Christopher L. Netherton, Guoqing Zhuang, Aijun Sun, Gaiping Zhang
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Viruses
Subjects:
African swine fever virus
African swine fever
dUTPase
epitope
therapeutic drug
Online Access:https://www.mdpi.com/1999-4915/13/11/2175

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https://www.mdpi.com/1999-4915/13/11/2175

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