Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms

Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms

(1) Background. The endocannabinoid (eCB) system, which regulates physiological and cognitive processes, presents a promising therapeutic target for treating HIV-associated neurocognitive disorders (HAND). Here we examine whether upregulating eCB tone has potential protective effects against HIV-1 T...

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Bibliographic Details
Main Authors: Changqing Xu, Barkha J. Yadav-Samudrala, Callie Xu, Bhupendra Nath, Twisha Mistry, Wei Jiang, Micah J. Niphakis, Benjamin F. Cravatt, Somnath Mukhopadhyay, Aron H. Lichtman, Bogna M. Ignatowska-Jankowska, Sylvia Fitting
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
endocannabinoids
neuroHIV
fatty acid amide hydrolase
Tat transgenic mice
inhibitory postsynaptic potentials
PF3845
Online Access:https://www.mdpi.com/2073-4409/11/5/857

Internet

https://www.mdpi.com/2073-4409/11/5/857

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