Development of Novel Epigenetic Anti-Cancer Therapy Targeting TET Proteins

Development of Novel Epigenetic Anti-Cancer Therapy Targeting TET Proteins

Epigenetic dysregulation, particularly alterations in DNA methylation and hydroxymethylation, plays a pivotal role in cancer initiation and progression. Ten-eleven translocation (TET) proteins catalyze the successive oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further o...

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Bibliographic Details
Main Authors: Hyejin Kim, Inkyung Jung, Chan Hyeong Lee, Jungeun An, Myunggon Ko
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
epigenetic dysregulation
TET proteins
DNA methylation
hydroxymethylation
cell-based screening
mitoxantrone
Online Access:https://www.mdpi.com/1422-0067/24/22/16375

Internet

https://www.mdpi.com/1422-0067/24/22/16375

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