Atorvastatin induces adrenal androgen downshift in men with prostate cancer: A post Hoc analysis of a pilot adaptive Randomised clinical trial

Atorvastatin induces adrenal androgen downshift in men with prostate cancer: A post Hoc analysis of a pilot adaptive Randomised clinical trial

Background: Prostate cancer (PCa) progression depends on androgen receptor activity. Cholesterol is required for biosynthesis of all steroid hormones, including androgens. Impact of cholesterol-lowering statins on androgens is unknown. We explored atorvastatin influence on serum and prostatic tissue...

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Bibliographic Details
Main Authors: Paavo V.H. Raittinen, Heimo Syvälä, Teuvo L.J. Tammela, Merja R. Häkkinen, Pauliina Ilmonen, Seppo Auriola, Teemu J. Murtola
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:EBioMedicine
Subjects:
Prostate cancer
Serum adrenal androgens
Prostatic tissue adrenal androgens
Statins
Clinical trial
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421002255

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http://www.sciencedirect.com/science/article/pii/S2352396421002255

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