The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90β

The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90β

Abstract Endothelial cell (EC) barrier disruption and inflammation are the pathological hallmarks of vascular disorders and acute infectious diseases and related conditions, including the coronavirus disease 2019 (COVID-19) and sepsis. Ubiquitination plays a critical role in regulating the stability...

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Bibliographic Details
Main Authors: Jiaxing Miao, Lian Li, Nargis Shaheen, Jianxin Wei, Anastasia M. Jacko, Prithu Sundd, Sarah J. Taleb, Rama K. Mallampalli, Yutong Zhao, Jing Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-024-01160-y

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https://doi.org/10.1038/s12276-024-01160-y

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