Mucus increases cell iron uptake to impact the release of pro-inflammatory mediators after particle exposure

Abstract We tested the hypothesis that (1) mucus production can be included in the cell response to iron deficiency; (2) mucus binds iron and increases cell metal uptake; and subsequently (3) mucus impacts the inflammatory response to particle exposure. Using quantitative PCR, RNA for both MUC5B and...

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Bibliographic Details
Main Authors: Andrew J. Ghio, Joleen M. Soukup, Lisa A. Dailey, Victor L. Roggli
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-30335-2