Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome

Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome

Down syndrome (DS) results in various degrees of cognitive deficits. In DS mouse models, recovery of behavioral and neurophysiological deficits using GABAAR antagonists led to hypothesize an excessive activity of inhibitory circuits in this condition. Nonetheless, whether over-inhibition is present...

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Bibliographic Details
Main Authors: Javier Zorrilla de San Martin, Cristina Donato, Jérémy Peixoto, Andrea Aguirre, Vikash Choudhary, Angela Michela De Stasi, Joana Lourenço, Marie-Claude Potier, Alberto Bacci
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
down syndrome
interneuron
gamma oscillations
prefrontal cortex
synaptic transmission
ts65dn
Online Access:https://elifesciences.org/articles/58731

Internet

https://elifesciences.org/articles/58731

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