Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate ALK1 Signaling in Endothelial Cells

Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate ALK1 Signaling in Endothelial Cells

Endothelial cells (ECs) respond to concurrent stimulation by biochemical factors and wall shear stress (SS) exerted by blood flow. Disruptions in flow-induced responses can result in remodeling issues and cardiovascular diseases, but the detailed mechanisms linking flow-mechanical cues and biochemic...

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Bibliographic Details
Main Authors: Ya-Wen Cheng, Anthony R. Anzell, Stefanie A. Morosky, Tristin A. Schwartze, Cynthia S. Hinck, Andrew P. Hinck, Beth L. Roman, Lance A. Davidson
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
endothelial cell biology
mechanotransduction
mechanobiology
mechanosensing
pSMAD1/5/9
ALK1 receptor trafficking
Online Access:https://www.mdpi.com/2073-4409/13/3/285

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https://www.mdpi.com/2073-4409/13/3/285

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