Pharmacokinetics of pure silybin diastereoisomers and identification of their metabolites in rat plasma

The flavonolignan silybin (isolated from the fruits of the milk thistle, Silybum marianum), is a mixture of two diastereoisomers and has anticancer, chemoprotective, hepatoprotective and dermatoprotective properties. This compound is largely used in various functional foods, nutraceutics and food su...

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Bibliographic Details
Main Authors: Petr Marhol, Petr Bednář, Petra Kolářová, Rostislav Večeřa, Jitka Ulrichová, Eva Tesařová, Eva Vavříková, Marek Kuzma, Vladimír Křen
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Journal of Functional Foods
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615000936