Constant Voltage Iontophoresis Technique to Deliver Terbinafine via Transungual Delivery System: Formulation Optimization Using Box–Behnken Design and In Vitro Evaluation

Constant Voltage Iontophoresis Technique to Deliver Terbinafine via Transungual Delivery System: Formulation Optimization Using Box–Behnken Design and In Vitro Evaluation

Topical therapy of antifungals is primarily restricted due to the low innate transport of drugs through the thick multi-layered keratinized nail plate. The objective of this investigation was to develop a gel formulation, and to optimize and evaluate the transungual delivery of terbinafine using the...

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Bibliographic Details
Main Authors: Anroop B. Nair, Bandar E. Al-Dhubiab, Jigar Shah, Bapi Gorain, Shery Jacob, Mahesh Attimarad, Nagaraja Sreeharsha, Katharigatta N. Venugopala, Mohamed A. Morsy
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
nail permeation
onychomycosis
enhancer
low voltage iontophoresis
Box–Behnken model
antifungal study
Online Access:https://www.mdpi.com/1999-4923/13/10/1692

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https://www.mdpi.com/1999-4923/13/10/1692

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