Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids

Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids

Multimodal single-cell analysis on iPSC-derived kidney organoids shows that inhibiting EZH2 attenuates TGFβ1-induced fibrotic gene expression and changes in chromatin accessibility, highlighting a potential therapeutic strategy for renal fibrosis.

Bibliographic Details
Main Authors: Jessica L. Davis, Ciaran Kennedy, Shane Clerkin, Niall J. Treacy, Thomas Dodd, Catherine Moss, Alison Murphy, Derek P. Brazil, Gerard Cagney, Dermot F. Brougham, Rabi Murad, Darren Finlay, Kristiina Vuori, John Crean
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04264-1

Internet

https://doi.org/10.1038/s42003-022-04264-1

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