Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids
Multimodal single-cell analysis on iPSC-derived kidney organoids shows that inhibiting EZH2 attenuates TGFβ1-induced fibrotic gene expression and changes in chromatin accessibility, highlighting a potential therapeutic strategy for renal fibrosis.
Bibliographic Details
Main Authors: |
Jessica L. Davis,
Ciaran Kennedy,
Shane Clerkin,
Niall J. Treacy,
Thomas Dodd,
Catherine Moss,
Alison Murphy,
Derek P. Brazil,
Gerard Cagney,
Dermot F. Brougham,
Rabi Murad,
Darren Finlay,
Kristiina Vuori,
John Crean |
Format: | Article
|
Language: | English |
Published: |
Nature Portfolio
2022-11-01
|
Series: | Communications Biology
|
Online Access: | https://doi.org/10.1038/s42003-022-04264-1
|