Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids
Multimodal single-cell analysis on iPSC-derived kidney organoids shows that inhibiting EZH2 attenuates TGFβ1-induced fibrotic gene expression and changes in chromatin accessibility, highlighting a potential therapeutic strategy for renal fibrosis.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04264-1 |
| _version_ | 1811187080216182784 |
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| author | Jessica L. Davis Ciaran Kennedy Shane Clerkin Niall J. Treacy Thomas Dodd Catherine Moss Alison Murphy Derek P. Brazil Gerard Cagney Dermot F. Brougham Rabi Murad Darren Finlay Kristiina Vuori John Crean |
| author_facet | Jessica L. Davis Ciaran Kennedy Shane Clerkin Niall J. Treacy Thomas Dodd Catherine Moss Alison Murphy Derek P. Brazil Gerard Cagney Dermot F. Brougham Rabi Murad Darren Finlay Kristiina Vuori John Crean |
| author_sort | Jessica L. Davis |
| collection | DOAJ |
| description | Multimodal single-cell analysis on iPSC-derived kidney organoids shows that inhibiting EZH2 attenuates TGFβ1-induced fibrotic gene expression and changes in chromatin accessibility, highlighting a potential therapeutic strategy for renal fibrosis. |
| first_indexed | 2024-04-11T13:55:59Z |
| format | Article |
| id | doaj.art-7c0970e160e847bc9ea14f1bd75e80a3 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-11T13:55:59Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-7c0970e160e847bc9ea14f1bd75e80a32022-12-22T04:20:20ZengNature PortfolioCommunications Biology2399-36422022-11-015111610.1038/s42003-022-04264-1Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoidsJessica L. Davis0Ciaran Kennedy1Shane Clerkin2Niall J. Treacy3Thomas Dodd4Catherine Moss5Alison Murphy6Derek P. Brazil7Gerard Cagney8Dermot F. Brougham9Rabi Murad10Darren Finlay11Kristiina Vuori12John Crean13UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, BelfieldUCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, BelfieldUCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, BelfieldUCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, BelfieldUCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, BelfieldUCD Genomics Core Facility, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, BelfieldUCD Genomics Core Facility, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, BelfieldWellcome-Wolfson Institute for Experimental Medicine, Queen’s University BelfastUCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, BelfieldUCD School of Chemistry, University College Dublin, BelfieldSanford Burnham Prebys Institute for Medical DiscoverySanford Burnham Prebys Institute for Medical DiscoverySanford Burnham Prebys Institute for Medical DiscoveryUCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, BelfieldMultimodal single-cell analysis on iPSC-derived kidney organoids shows that inhibiting EZH2 attenuates TGFβ1-induced fibrotic gene expression and changes in chromatin accessibility, highlighting a potential therapeutic strategy for renal fibrosis.https://doi.org/10.1038/s42003-022-04264-1 |
| spellingShingle | Jessica L. Davis Ciaran Kennedy Shane Clerkin Niall J. Treacy Thomas Dodd Catherine Moss Alison Murphy Derek P. Brazil Gerard Cagney Dermot F. Brougham Rabi Murad Darren Finlay Kristiina Vuori John Crean Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids Communications Biology |
| title | Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids |
| title_full | Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids |
| title_fullStr | Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids |
| title_full_unstemmed | Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids |
| title_short | Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids |
| title_sort | single cell multiomics reveals the complexity of tgfβ signalling to chromatin in ipsc derived kidney organoids |
| url | https://doi.org/10.1038/s42003-022-04264-1 |
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