NF-κB drives epithelial-mesenchymal mechanisms of lung fibrosis in a translational lung cell model

NF-κB drives epithelial-mesenchymal mechanisms of lung fibrosis in a translational lung cell model

In the progression phase of idiopathic pulmonary fibrosis (IPF), the normal alveolar structure of the lung is lost and replaced by remodeled fibrotic tissue and by bronchiolized cystic airspaces. Although these are characteristic features of IPF, knowledge of specific interactions between these path...

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Bibliographic Details
Main Authors: Patrick Sieber, Anny Schäfer, Raphael Lieberherr, Silvia L. Caimi, Urs Lüthi, Jesper Ryge, Jan H. Bergmann, François Le Goff, Manuel Stritt, Peter Blattmann, Bérengère Renault, Patrick Rammelt, Bruno Sempere, Diego Freti, Rolf Studer, Eric S. White, Magdalena Birker-Robaczewska, Maxime Boucher, Oliver Nayler
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-02-01
Series:JCI Insight
Subjects:
Cell biology
Pulmonology
Online Access:https://doi.org/10.1172/jci.insight.154719

Internet

https://doi.org/10.1172/jci.insight.154719

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