A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing

A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing

The proteolytic active sites of the 26S proteasome are sequestered within the catalytic chamber of its 20S core particle (CP). Access to this chamber is through a narrow channel defined by the seven outer α subunits. In the resting state, the N-termini of neighboring α subunits form a gate blocking...

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Bibliographic Details
Main Authors: Indrajit Sahu, Monika Bajorek, Xiaolin Tan, Madabhushi Srividya, Daria Krutauz, Noa Reis, Pawel A. Osmulski, Maria E. Gaczynska, Michael H. Glickman
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomolecules
Subjects:
proteasome
ubiquitin
20S gating
proteolysis
substrate translocation
Online Access:https://www.mdpi.com/2218-273X/13/3/480

Internet

https://www.mdpi.com/2218-273X/13/3/480

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