Effect of Collagen Matrix on Doxorubicin Distribution and Cancer Cells’ Response to Treatment in 3D Tumor Model

Effect of Collagen Matrix on Doxorubicin Distribution and Cancer Cells’ Response to Treatment in 3D Tumor Model

The extracellular matrix (ECM) plays an important role in regulation of many aspects of tumor growth and response to therapies. However, the specifics of the interaction of chemotherapeutic agents with cancer cells in the presence of collagen, the major component of ECM, is still poorly investigated...

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Bibliographic Details
Main Authors: Irina Druzhkova, Elena Nikonova, Nadezhda Ignatova, Irina Koryakina, Mikhail Zyuzin, Artem Mozherov, Dmitriy Kozlov, Dmitry Krylov, Daria Kuznetsova, Uliyana Lisitsa, Vladislav Shcheslavskiy, Evgeny A. Shirshin, Elena Zagaynova, Marina Shirmanova
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
drug delivery
cancer metabolism
NAD(P)H
extracellular matrix
Doxorubicin
microfluidic chip
Online Access:https://www.mdpi.com/2072-6694/14/22/5487

Internet

https://www.mdpi.com/2072-6694/14/22/5487

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