Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation

Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation

Abstract The prenylation of proteins is involved in a variety of biological functions. However, it remains unknown whether it plays an important role in the morphogenesis of the cerebellum. To address this question, we generated a mouse model, in which the geranylgeranyl pyrophosphate synthase (Ggps...

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Bibliographic Details
Main Authors: Qi Cheng, Jing Wu, Yingqian Xia, Qing Cheng, Yinjuan Zhao, Peixiang Zhu, Wangling Zhang, Shihu Zhang, Lei Zhang, Yushan Yuan, Chaojun Li, Guiquan Chen, Bin Xue
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Molecular Brain
Subjects:
Ataxia
Cerebellum
Ggpps
Proliferation
Protein prenylation
Online Access:https://doi.org/10.1186/s13041-023-01010-4

Internet

https://doi.org/10.1186/s13041-023-01010-4

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