Exosomal long noncoding RNA MLETA1 promotes tumor progression and metastasis by regulating the miR-186-5p/EGFR and miR-497-5p/IGF1R axes in non-small cell lung cancer

Exosomal long noncoding RNA MLETA1 promotes tumor progression and metastasis by regulating the miR-186-5p/EGFR and miR-497-5p/IGF1R axes in non-small cell lung cancer

Abstract Background Lung cancer is the most common and deadliest cancer worldwide, and approximately 90% of all lung cancer deaths are caused by tumor metastasis. Tumor-derived exosomes could potentially promote tumor metastasis through the delivery of metastasis-related molecules. However, the func...

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Bibliographic Details
Main Authors: Xiu-Rui Hsu, Jia-En Wu, Yi-Ying Wu, Sheng-Yen Hsiao, Jui-Lin Liang, Ya-Ju Wu, Chia-Hao Tung, Meng-Fan Huang, Ming-Shiu Lin, Pan-Chyr Yang, Yuh-Ling Chen, Tse-Ming Hong
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lnc-MLETA1
Lung cancer metastasis
Exosome
miR-186-5p
miR-497-5p
IGF1R
Online Access:https://doi.org/10.1186/s13046-023-02859-y

Internet

https://doi.org/10.1186/s13046-023-02859-y

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