CVM-1118 (foslinanib), a 2-phenyl-4-quinolone derivative, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1

CVM-1118 (foslinanib), a 2-phenyl-4-quinolone derivative, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1

CVM-1118 (foslinanib) is a phosphoric ester compound selected from 2-phenyl-4-quinolone derivatives. The NCI 60 cancer panel screening showed CVM-1125, the major active metabolite of CVM-1118, to exhibit growth inhibitory and cytotoxic effects at nanomolar range. CVM-1118 possesses multiple bioactiv...

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Bibliographic Details
Main Authors: Lifen Shen, Yen-Ling Chen, Chu-Chun Huang, Yu-Chiau Shyu, Richard E. B. Seftor, Elisabeth A. Seftor, Mary J. C. Hendrix, Du-Shieng Chien, Yi-Wen Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Pathology and Oncology Research
Subjects:
TRAP1
vasculogenic mimicry
CVM-1118
foslinanib
Hsp75
STK11
Online Access:https://www.por-journal.com/articles/10.3389/pore.2023.1611038/full

Internet

https://www.por-journal.com/articles/10.3389/pore.2023.1611038/full

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