Transcription factor E4F1 dictates spermatogonial stem cell fate decisions by regulating mitochondrial functions and cell cycle progression

Transcription factor E4F1 dictates spermatogonial stem cell fate decisions by regulating mitochondrial functions and cell cycle progression

Abstract Background Spermatogonial stem cells (SSCs) provide a foundation for robust and continual spermatogenesis in mammals. SSCs self-renew to maintain a functional stem cell pool and differentiate to supply committed progenitors. Metabolism acts as a crucial determinant of stem cell fates; howev...

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Bibliographic Details
Main Authors: Rong-Ge Yan, Zhen He, Fei-Chen Wang, Shuang Li, Qin-Bang Shang, Qi-En Yang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cell & Bioscience
Subjects:
Spermatogenesis
Spermatogonial stem cell
Oxidative phosphorylation
Metabolism
Fate decisions
Transcription factor
Online Access:https://doi.org/10.1186/s13578-023-01134-z

Internet

https://doi.org/10.1186/s13578-023-01134-z

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