TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells

TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells

Emerging evidence indicates that the TRPM8 channel plays an important role in prostate cancer (PCa) progression, by impairing the motility of these cancer cells. Here, we reveal a novel facet of PCa motility control via direct protein-protein interaction (PPI) of the channel with the small GTPase Ra...

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Bibliographic Details
Main Authors: Giorgia Chinigò, Guillaume P. Grolez, Madelaine Audero, Alexandre Bokhobza, Michela Bernardini, Julien Cicero, Robert-Alain Toillon, Quentin Bailleul, Luca Visentin, Federico Alessandro Ruffinatti, Guillaume Brysbaert, Marc F. Lensink, Jerome De Ruyck, Anna Rita Cantelmo, Alessandra Fiorio Pla, Dimitra Gkika
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
prostate cancer
metastasis
TRPM8
Rap1A
migration
adhesion
Online Access:https://www.mdpi.com/2072-6694/14/9/2261

Internet

https://www.mdpi.com/2072-6694/14/9/2261

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