miR-378b Regulates Insulin Sensitivity by Targeting Insulin Receptor and p110α in Alcohol-Induced Hepatic Steatosis

miR-378b Regulates Insulin Sensitivity by Targeting Insulin Receptor and p110α in Alcohol-Induced Hepatic Steatosis

Insulin resistance has been implicated in alcoholic liver disease. A previous study has shown that microRNAs (miRNAs) play a major role in the production, secretion, and function of insulin. MiRNAs are capable of repressing multiple target genes that in turn negatively regulate various physiological...

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Bibliographic Details
Main Authors: Yuan-yuan Li, Yu-juan Zhong, Qi Cheng, Ying-zhao Wang, Yuan-yuan Fan, Cheng-fang Yang, Zuheng Ma, Yong-wen Li, Li Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
MiR-378b
insulin resistance
insulin receptor
p110α
alcoholic hepatic steatosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00717/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00717/full

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