Activation of α7nAChR by PNU282987 improves cognitive impairment through inhibiting oxidative stress and neuroinflammation in D-galactose induced aging via regulating α7nAChR/Nrf2/HO-1 signaling pathway

Activation of α7nAChR by PNU282987 improves cognitive impairment through inhibiting oxidative stress and neuroinflammation in D-galactose induced aging via regulating α7nAChR/Nrf2/HO-1 signaling pathway

Aging is an important risk factor for neurodegenerative diseases. The activation of α7 nicotinic acetylcholine receptor (α7nAChR) is involved in inflammation and cognition, but the specific role it plays in aging remains unknown. This study aimed to investigate the anti-aging effect of the activatio...

Full description

Bibliographic Details
Main Authors: Yawen Zhang, Rui Ma, Wencheng Wang, Qian Deng, Chi Cao, Chunyang Yu, Shulin Li, Lei Shi, Jianying Tian
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Experimental Gerontology
Subjects:
Aging
Oxidative stress
Neuroinflammation
α7nAChR
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556523000608

Internet

http://www.sciencedirect.com/science/article/pii/S0531556523000608

Similar Items