Engineering a Humanised Niche to Support Human Haematopoiesis in Mice: Novel Opportunities in Modelling Cancer

Engineering a Humanised Niche to Support Human Haematopoiesis in Mice: Novel Opportunities in Modelling Cancer

Despite the bone marrow microenvironment being widely recognised as a key player in cancer research, the current animal models that represent a human haematopoietic system lack the contribution of the humanised marrow microenvironment. Here we describe a murine model that relies on the combination o...

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Bibliographic Details
Main Authors: Alvaro Sanchez-Herrero, Isabel A. Calvo, Maria Flandes-Iparraguirre, Marietta Landgraf, Christoph A. Lahr, Abbas Shafiee, Froilán Granero-Molto, Borja Saez, Manuel M. Mazo, Bruno Paiva, Elena de Juan Pardo, Andrew Nicol, Felipe Prosper, Laura J. Bray, Jacqui A. McGovern
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
humanised mouse model
bone marrow
tumour microenvironment
CD34+ haematopoietic stem cell
tissue engineering
multiple myeloma
Online Access:https://www.mdpi.com/2072-6694/12/8/2205

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https://www.mdpi.com/2072-6694/12/8/2205

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