Sonic Hedgehog modulates EGFR dependent proliferation of Neural Stem Cells during late mouse embryogenesis through EGFR Transactivation.

Sonic Hedgehog modulates EGFR dependent proliferation of Neural Stem Cells during late mouse embryogenesis through EGFR Transactivation.

Sonic Hedgehog (Shh/GLI) and EGFR signaling pathways modulate Neural Stem Cell (NSC) proliferation. How these signals cooperate is therefore critical for understanding normal brain development and function. Here we report a novel acute effect of Shh signaling on EGFR function. We show that during la...

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Bibliographic Details
Main Authors: Veronica Alejandra Palma, Gisela eReinchisi, Margarita eParada, Claudia eOyanadel, Ronan eShaughnessy, Pablo eLois, Alfonso eGonzalez
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cancer
EGFR
Shh
proliferation
neural progenitors
radial glial cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00166/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00166/full

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