Sonic Hedgehog modulates EGFR dependent proliferation of Neural Stem Cells during late mouse embryogenesis through EGFR Transactivation.
Sonic Hedgehog (Shh/GLI) and EGFR signaling pathways modulate Neural Stem Cell (NSC) proliferation. How these signals cooperate is therefore critical for understanding normal brain development and function. Here we report a novel acute effect of Shh signaling on EGFR function. We show that during la...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-09-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00166/full |
| _version_ | 1831813777277845504 |
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| author | Veronica Alejandra Palma Gisela eReinchisi Gisela eReinchisi Gisela eReinchisi Margarita eParada Margarita eParada Claudia eOyanadel Ronan eShaughnessy Pablo eLois Alfonso eGonzalez |
| author_facet | Veronica Alejandra Palma Gisela eReinchisi Gisela eReinchisi Gisela eReinchisi Margarita eParada Margarita eParada Claudia eOyanadel Ronan eShaughnessy Pablo eLois Alfonso eGonzalez |
| author_sort | Veronica Alejandra Palma |
| collection | DOAJ |
| description | Sonic Hedgehog (Shh/GLI) and EGFR signaling pathways modulate Neural Stem Cell (NSC) proliferation. How these signals cooperate is therefore critical for understanding normal brain development and function. Here we report a novel acute effect of Shh signaling on EGFR function. We show that during late neocortex development, Shh mediates the activation of the ERK1/2 signaling pathway in Radial Glial cells through EGFR transactivation. This process is dependent on metalloprotease activity and accounts for almost 50% of the EGFR-dependent mitogenic response of late NSCs. Furthermore, in HeLa cancer cells, a well-known model for studying the EGFR receptor function, Shh also induces cell proliferation involving EGFR activation, as reflected by EGFR internalization and ERK1/2 phosphorylation. These findings may have important implications for understanding the mechanisms that regulate NSC proliferation during neurogenesis and may lead to novel approaches to the treatment of tumors. |
| first_indexed | 2024-12-22T22:01:25Z |
| format | Article |
| id | doaj.art-7c16a7635e4b4d99be225e537c9f56f2 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-22T22:01:25Z |
| publishDate | 2013-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-7c16a7635e4b4d99be225e537c9f56f22022-12-21T18:11:07ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022013-09-01710.3389/fncel.2013.0016656833Sonic Hedgehog modulates EGFR dependent proliferation of Neural Stem Cells during late mouse embryogenesis through EGFR Transactivation.Veronica Alejandra Palma0Gisela eReinchisi1Gisela eReinchisi2Gisela eReinchisi3Margarita eParada4Margarita eParada5Claudia eOyanadel6Ronan eShaughnessy7Pablo eLois8Alfonso eGonzalez9University of ChileUniversity of ChilePontificia Universidad Catolica de ChileUniversity of Connecticut Health CenterUniversity of ChilePontificia Universidad Catolica de ChilePontificia Universidad Catolica de ChilePontificia Universidad Catolica de ChileUniversity of ChilePontificia Universidad Catolica de ChileSonic Hedgehog (Shh/GLI) and EGFR signaling pathways modulate Neural Stem Cell (NSC) proliferation. How these signals cooperate is therefore critical for understanding normal brain development and function. Here we report a novel acute effect of Shh signaling on EGFR function. We show that during late neocortex development, Shh mediates the activation of the ERK1/2 signaling pathway in Radial Glial cells through EGFR transactivation. This process is dependent on metalloprotease activity and accounts for almost 50% of the EGFR-dependent mitogenic response of late NSCs. Furthermore, in HeLa cancer cells, a well-known model for studying the EGFR receptor function, Shh also induces cell proliferation involving EGFR activation, as reflected by EGFR internalization and ERK1/2 phosphorylation. These findings may have important implications for understanding the mechanisms that regulate NSC proliferation during neurogenesis and may lead to novel approaches to the treatment of tumors.http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00166/fullCancerEGFRShhproliferationneural progenitorsradial glial cells |
| spellingShingle | Veronica Alejandra Palma Gisela eReinchisi Gisela eReinchisi Gisela eReinchisi Margarita eParada Margarita eParada Claudia eOyanadel Ronan eShaughnessy Pablo eLois Alfonso eGonzalez Sonic Hedgehog modulates EGFR dependent proliferation of Neural Stem Cells during late mouse embryogenesis through EGFR Transactivation. Frontiers in Cellular Neuroscience Cancer EGFR Shh proliferation neural progenitors radial glial cells |
| title | Sonic Hedgehog modulates EGFR dependent proliferation of Neural Stem Cells during late mouse embryogenesis through EGFR Transactivation. |
| title_full | Sonic Hedgehog modulates EGFR dependent proliferation of Neural Stem Cells during late mouse embryogenesis through EGFR Transactivation. |
| title_fullStr | Sonic Hedgehog modulates EGFR dependent proliferation of Neural Stem Cells during late mouse embryogenesis through EGFR Transactivation. |
| title_full_unstemmed | Sonic Hedgehog modulates EGFR dependent proliferation of Neural Stem Cells during late mouse embryogenesis through EGFR Transactivation. |
| title_short | Sonic Hedgehog modulates EGFR dependent proliferation of Neural Stem Cells during late mouse embryogenesis through EGFR Transactivation. |
| title_sort | sonic hedgehog modulates egfr dependent proliferation of neural stem cells during late mouse embryogenesis through egfr transactivation |
| topic | Cancer EGFR Shh proliferation neural progenitors radial glial cells |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00166/full |
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