Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 correlate with tuft cell abundance and marker expression in silico

Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 correlate with tuft cell abundance and marker expression in silico

Abstract Colorectal cancer (CRC) is characterised by heritable risk that is not well understood. Heritable, genetic variation at 11q23.1 is associated with increased colorectal cancer (CRC) risk, demonstrating eQTL effects on 3 cis- and 23 trans-eQTL targets. We sought to determine the relationship...

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Bibliographic Details
Main Authors: Bradley T. Harris, Vidya Rajasekaran, James P. Blackmur, Alan O’Callaghan, Kevin Donnelly, Maria Timofeeva, Peter G. Vaughan-Shaw, Farhat V. N. Din, Malcolm G. Dunlop, Susan M. Farrington
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-17887-5

Internet

https://doi.org/10.1038/s41598-022-17887-5

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