Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability

Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability

Sirtuin 5 (SIRT5) has been associated to colorectal cancer and metabolic regulation. Here, the authors show that SIRT5 silencing reduces nucleotide availability leading to DNA damage and tumor suppression in colorectal cancer models.

Bibliographic Details
Main Authors: Hao-Lian Wang, Yan Chen, Yun-Qian Wang, En-Wei Tao, Juan Tan, Qian-Qian Liu, Chun-Min Li, Xue-Mei Tong, Qin-Yan Gao, Jie Hong, Ying-Xuan Chen, Jing-Yuan Fang
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33903-8

Internet

https://doi.org/10.1038/s41467-022-33903-8

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