Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

Abstract The protein α-synuclein (αsyn) forms pathologic aggregates in a number of neurodegenerative diseases including Lewy body dementia (LBD) and Parkinson’s disease (PD). It is unclear why diseases such as LBD may develop widespread αsyn pathology, while in Alzheimer’s disease with amygdala rest...

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Bibliographic Details
Main Authors: Zachary A. Sorrentino, Marshall S. Goodwin, Cara J. Riffe, Jess-Karan S. Dhillon, Yuxing Xia, Kimberly-Marie Gorion, Niran Vijayaraghavan, Karen N. McFarland, Lawrence I. Golbe, Anthony T. Yachnis, Benoit I. Giasson
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Acta Neuropathologica Communications
Subjects:
α-Synuclein
Parkinson’s disease
Lewy body dementia
Truncation
Amygdala
Inclusion formation
Online Access:http://link.springer.com/article/10.1186/s40478-019-0787-2

Internet

http://link.springer.com/article/10.1186/s40478-019-0787-2

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