PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression

PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression

Abstract Fluxes in human copper levels recently garnered attention for roles in cellular signaling, including affecting levels of the signaling molecule cyclic adenosine monophosphate. We herein apply an unbiased temporal evaluation of the signaling and whole genome transcriptional activities modula...

Full description

Bibliographic Details
Main Authors: Matthew O. Ross, Yuan Xie, Ryan C. Owyang, Chang Ye, Olivia N. P. Zbihley, Ruitu Lyu, Tong Wu, Pingluan Wang, Olga Karginova, Olufunmilayo I. Olopade, Minglei Zhao, Chuan He
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-50524-5

Internet

https://doi.org/10.1038/s41467-024-50524-5

Similar Items