The Role of the RANKL/RANK Axis in the Prevention and Treatment of Breast Cancer with Immune Checkpoint Inhibitors and Anti-RANKL

The Role of the RANKL/RANK Axis in the Prevention and Treatment of Breast Cancer with Immune Checkpoint Inhibitors and Anti-RANKL

The receptor activator of nuclear factor-κB (RANK) and the RANK ligand (RANKL) were reported in the regulation of osteoclast differentiation/activation and bone homeostasis. Additionally, the RANKL/RANK axis is a significant mediator of progesterone-driven mammary epithelial cell proliferation, pote...

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Bibliographic Details
Main Authors: Aristofania Simatou, Panagiotis Sarantis, Evangelos Koustas, Athanasios G. Papavassiliou, Michalis V. Karamouzis
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
RANK
RANKL
EGFR
ERBB2
immune checkpoint inhibitors
denosumab
Online Access:https://www.mdpi.com/1422-0067/21/20/7570

Internet

https://www.mdpi.com/1422-0067/21/20/7570

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