Combined Inhibition of Akt and mTOR Is Effective Against Non-Hodgkin Lymphomas

Non-Hodgkin lymphoma (NHL) are a diverse group of hematological malignancies comprised of over 60 subtypes. These subtypes range from indolent to aggressive. The PI3K/Akt/mTOR pathway has been shown to contribute to cell survival and proliferation and is constitutively active in most NHL. MK-7075 (m...

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Bibliographic Details
Main Authors: Ricardo Rivera-Soto, Yi Yu, Dirk P. Dittmer, Blossom Damania
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.670275/full