Effects of statins on the inducible degrader of low-density lipoprotein receptor in familial hypercholesterolemia

Effects of statins on the inducible degrader of low-density lipoprotein receptor in familial hypercholesterolemia

The inducible degrader of low-density lipoprotein receptor (IDOL) is an E3 ubiquitin ligase involved in the post-transcriptional regulation of LDL receptor (LDLR). Statins lower plasma LDL by activating transcription of hepatic LDLR expression, and we have determined whether statins modulate IDOL ex...

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Bibliographic Details
Main Authors: Melody Lok-Yi Chan, Sammy Wing-Ming Shiu, Ching-Lung Cheung, Anskar Yu-Hung Leung, Kathryn Choon-Beng Tan
Format: Article
Language:English
Published: Bioscientifica 2022-06-01
Series:Endocrine Connections
Subjects:
ubiquitin-protein ligases
lipid metabolism
statin therapy
familial hypercholesterolemia
low-density lipoprotein
Online Access:https://ec.bioscientifica.com/view/journals/ec/11/6/EC-22-0019.xml

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https://ec.bioscientifica.com/view/journals/ec/11/6/EC-22-0019.xml

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