Synthesis of new para-aminobenzoic acid derivatives, in vitro biological evaluation and preclinical validation of DAB-2-28 as a therapeutic option for the treatment of bladder cancer

Synthesis of new para-aminobenzoic acid derivatives, in vitro biological evaluation and preclinical validation of DAB-2-28 as a therapeutic option for the treatment of bladder cancer

Chronic inflammation plays a crucial role in bladder cancer (BCa) development and progression. To offer a unique treatment opportunity for this type of cancer, a hydrazide derivative namely, DAB-1, was recently identified in our laboratory as a potential drug to target cancer-related inflammation. I...

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Bibliographic Details
Main Authors: Yassine Oufqir, Laurie Fortin, Julie Girouard, Francis Cloutier, Maude Cloutier, Marie-France Leclerc, Denise Belgorosky, Ana María Eiján, Gervais Bérubé, Carlos Reyes-Moreno
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Aminobenzoic acid
Bladder cancer
Hydrazide derivatives
Inflammation
Interferon gamma
Interleukin 6
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417422000413

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http://www.sciencedirect.com/science/article/pii/S2772417422000413

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