Successful Production of Offspring Derived from Phospholipase C Zeta-Deficient Sperm by Additional Artificial Activation

Successful Production of Offspring Derived from Phospholipase C Zeta-Deficient Sperm by Additional Artificial Activation

During mammalian fertilization, repetitive rises of intracellular calcium called calcium oscillations are required for full activation of oocytes. Therefore, oocytes such as round spermatid injected or somatic cell nuclear transferred require additional artificial activation which mimics the calcium...

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Bibliographic Details
Main Authors: Naoki Hirose, Yasuyuki Kikuchi, Atsuko Kageyama, Hibiki Sugita, Miu Sakurai, Yui Kawata, Jumpei Terakawa, Teruhiko Wakayama, Junya Ito, Naomi Kashiwazaki
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Life
Subjects:
oocyte activation
sperm factor
phospholipase c
calcium
fertilization
Online Access:https://www.mdpi.com/2075-1729/13/4/980

Internet

https://www.mdpi.com/2075-1729/13/4/980

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