The Influence of Pressure on the Intrinsic Dissolution Rate of Amorphous Indomethacin

The Influence of Pressure on the Intrinsic Dissolution Rate of Amorphous Indomethacin

New drug candidates increasingly tend to be poorly water soluble. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. Intrinsic dissolution testing is an efficient standard method to determine the intrinsic dissolution rate (IDR) of a drug...

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Bibliographic Details
Main Authors: Korbinian Löbmann, Konstantina Flouda, Danwen Qiu, Theodosia Tsolakou, Wenbo Wang, Thomas Rades
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Pharmaceutics
Subjects:
amorphous
crystalline
dissolution
compression pressure
indomethacin
Online Access:http://www.mdpi.com/1999-4923/6/3/481

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http://www.mdpi.com/1999-4923/6/3/481

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