Histone and DNA Methylation as Epigenetic Regulators of DNA Damage Repair in Gastric Cancer and Emerging Therapeutic Opportunities

Histone and DNA Methylation as Epigenetic Regulators of DNA Damage Repair in Gastric Cancer and Emerging Therapeutic Opportunities

Gastric cancer (GC), one of the most common malignancies worldwide, is a heterogeneous disease developing from the accumulation of genetic and epigenetic changes. One of the most critical epigenetic alterations in GC is DNA and histone methylation, which affects multiple processes in the cell nucleu...

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Bibliographic Details
Main Authors: Katia De Marco, Paola Sanese, Cristiano Simone, Valentina Grossi
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
gastric cancer
epigenetic alterations
methylation
histone methyltransferases
DNA damage repair
homologous recombination deficiency
Online Access:https://www.mdpi.com/2072-6694/15/20/4976

Internet

https://www.mdpi.com/2072-6694/15/20/4976

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