CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations
BACKGROUND: CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplanta...
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| Format: | Article |
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BMC
2015-01-01
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| Series: | Biological Research |
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| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100041&lng=en&tlng=en |
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| author | Hiroshi Takahashi Kazuhiko Ikeda Kazuei Ogawa Syunnichi Saito Alain M Ngoma Yumiko Mashimo Koki Ueda Miki Furukawa Akiko Shichishima-Nakamura Hiroshi Ohkawara Kenneth E Nollet Hitoshi Ohto Yasuchika Takeishi |
| author_facet | Hiroshi Takahashi Kazuhiko Ikeda Kazuei Ogawa Syunnichi Saito Alain M Ngoma Yumiko Mashimo Koki Ueda Miki Furukawa Akiko Shichishima-Nakamura Hiroshi Ohkawara Kenneth E Nollet Hitoshi Ohto Yasuchika Takeishi |
| author_sort | Hiroshi Takahashi |
| collection | DOAJ |
| description | BACKGROUND: CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable. RESULTS: We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher proportions of total Treg cells 1 month post allo-HSCT, and naïve Treg cells 1 year post allo-HSCT, appeared in patients achieving complete chimera without developing significant chronic GVHD, including our thymectomized patient, compared with patients who developed chronic GVHD. CONCLUSIONS: Treg cells that modulate human allogeneic immunity may arise peripherally as well as in the thymus of allo-HSCT recipients. |
| first_indexed | 2024-12-20T19:34:11Z |
| format | Article |
| id | doaj.art-7c37fd6056dc4a81b3101afb51943a0e |
| institution | Directory Open Access Journal |
| issn | 0716-9760 |
| language | English |
| last_indexed | 2024-12-20T19:34:11Z |
| publishDate | 2015-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj.art-7c37fd6056dc4a81b3101afb51943a0e2022-12-21T19:28:43ZengBMCBiological Research0716-97602015-01-014801810.1186/S40659-015-0033-8S0716-97602015000100041CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantationsHiroshi Takahashi0Kazuhiko Ikeda1Kazuei Ogawa2Syunnichi Saito3Alain M Ngoma4Yumiko Mashimo5Koki Ueda6Miki Furukawa7Akiko Shichishima-Nakamura8Hiroshi Ohkawara9Kenneth E Nollet10Hitoshi Ohto11Yasuchika TakeishiFukushima Medical UniversityFukushima Medical UniversityFukushima Medical UniversityFukushima Medical UniversityFukushima Medical UniversityFukushima Medical UniversityFukushima Medical UniversityFukushima Medical UniversityFukushima Medical UniversityFukushima Medical UniversityFukushima Medical UniversityFukushima Medical UniversityBACKGROUND: CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable. RESULTS: We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher proportions of total Treg cells 1 month post allo-HSCT, and naïve Treg cells 1 year post allo-HSCT, appeared in patients achieving complete chimera without developing significant chronic GVHD, including our thymectomized patient, compared with patients who developed chronic GVHD. CONCLUSIONS: Treg cells that modulate human allogeneic immunity may arise peripherally as well as in the thymus of allo-HSCT recipients.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100041&lng=en&tlng=enRegulatory T cellsAllogeneic hematopoietic stem cell transplantationThymusGraft-versus-host disease |
| spellingShingle | Hiroshi Takahashi Kazuhiko Ikeda Kazuei Ogawa Syunnichi Saito Alain M Ngoma Yumiko Mashimo Koki Ueda Miki Furukawa Akiko Shichishima-Nakamura Hiroshi Ohkawara Kenneth E Nollet Hitoshi Ohto Yasuchika Takeishi CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations Biological Research Regulatory T cells Allogeneic hematopoietic stem cell transplantation Thymus Graft-versus-host disease |
| title | CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations |
| title_full | CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations |
| title_fullStr | CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations |
| title_full_unstemmed | CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations |
| title_short | CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations |
| title_sort | cd4 t cells in aged or thymectomized recipients of allogeneic stem cell transplantations |
| topic | Regulatory T cells Allogeneic hematopoietic stem cell transplantation Thymus Graft-versus-host disease |
| url | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100041&lng=en&tlng=en |
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