Dxr is essential in <it>Mycobacterium tuberculosis </it>and fosmidomycin resistance is due to a lack of uptake
<p>Abstract</p> <p>Fosmidomycin is a phosphonic antibiotic which inhibits 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr), the first committed step of the non-mevalonate pathway of isoprenoid biosynthesis. In <it>Mycobacterium tuberculosis </it>Dxr is encoded by R...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-05-01
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| Series: | BMC Microbiology |
| Online Access: | http://www.biomedcentral.com/1471-2180/8/78 |