Sevoflurane exposure causes neuronal apoptosis and cognitive dysfunction by inducing ER stress via activation of the inositol 1, 4, 5-trisphosphate receptor

Sevoflurane exposure causes neuronal apoptosis and cognitive dysfunction by inducing ER stress via activation of the inositol 1, 4, 5-trisphosphate receptor

The role of the inositol 1, 4, 5-trisphosphate receptor (IP3R) in hippocampal neuronal apoptosis and cognitive dysfunction induced by sevoflurane is currently unclear. Therefore, in this study, we investigated the role of the IP3R in endoplasmic reticulum (ER) stress and hippocampal neuronal apoptos...

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Bibliographic Details
Main Authors: Qi Zhang, Yanan Li, Xupeng Wang, Chunping Yin, Qi Zhou, Junfei Guo, Juan Zhao, Xiaohui Xian, Zhiyong Hou, Qiujun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
sevoflurane
cognitive dysfunction
IP3R
neuroapoptosis
calcium
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.990679/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.990679/full

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