Extrachromosomal Circular DNA: Current Knowledge and Implications for CNS Aging and Neurodegeneration

Extrachromosomal Circular DNA: Current Knowledge and Implications for CNS Aging and Neurodegeneration

Still unresolved is the question of how a lifetime accumulation of somatic gene copy number alterations impact organ functionality and aging and age-related pathologies. Such an issue appears particularly relevant in the broadly post-mitotic central nervous system (CNS), where non-replicative neuron...

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Bibliographic Details
Main Authors: Quratul Ain, Christian Schmeer, Diane Wengerodt, Otto W. Witte, Alexandra Kretz
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
alternative lengthening of telomeres (ALT)
CNS aging
copy number variants (CNV)
DNA repair
extrachromosomal circular DNA (ecc/ecDNA)
genomic plasticity
Online Access:https://www.mdpi.com/1422-0067/21/7/2477

Internet

https://www.mdpi.com/1422-0067/21/7/2477

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